The program of solid-state chemistry is a continuation of the main fundamental subjects that have been pointed out earlier in the lecture course of Material Science. The Solid- State Chemistry has emerged as a very important element in the education of the modern material science. In the lectures are underlined the main principals concerning the control of the phase transitions and chemical solid-state reactions. This includes understanding of their mechanism thermodynamics and kinetics. The crucial role of the structural imperfections (point defects, dislocations, grain boundaries and non- stoichiometry) is discussed in order to control the optical, electrical, magnetic and chemical properties. The laboratory exercises deal with the reactivity of solids, the nature of solid-state reactions and the application of the scientific rules for materials design.